| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acetylcholinesterase |
|---|
| Ligand | BDBM50467883 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1797233 (CHEMBL4269350) |
|---|
| IC50 | 200±n/a nM |
|---|
| Citation |  Knutsson, S; Engdahl, C; Kumari, R; Forsgren, N; Lindgren, C; Kindahl, T; Kitur, S; Wachira, L; Kamau, L; Ekström, F; Linusson, A Noncovalent Inhibitors of Mosquito Acetylcholinesterase 1 with Resistance-Breaking Potency. J Med Chem61:10545-10557 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acetylcholinesterase |
|---|
| Name: | Acetylcholinesterase |
|---|
| Synonyms: | Acetylcholinesterase | ace-1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 78192.84 |
|---|
| Organism: | Aedes aegypti |
|---|
| Description: | ChEMBL_117852 |
|---|
| Residue: | 702 |
|---|
| Sequence: | MEIRGLITRLLGPCHIRHLILCSLGIYSILVQSVHCRHHDIGSSTAHQLGSKYSQSSSLS
SSSQSSSSLVEDPVLNKDSDAFFTPYIGHGDSVRIVDAELGTLEREHVHSTTTRRRGLTR
RESSSDGTDNDPLLITTDKGKVRGLTLEAPSGKKVDAWLGIPYAQPPLGPLRFRHPRPVE
KWTGVLNATTPPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYINVVVPHPRPKNSAVM
LWIFGGGFYSGTATLDVYDHRTLASEENVIVVSLQYRVASLGFLFLGTPEAPGNAGLFDQ
NLALRWVRDNIHKFGGDPSRVTLFGESAGAVSVSLHLLSALSRDLFQRAILQSGSPTAPW
ALVSREEATLRALRLAEAVNCPHDATKLTDTVECLRTKDPNVLVDNEWGTLGICEFPFVP
VVDGAFLDETPQRSLASGRFKKTDILTGSNTEEGYYFIIYYLTELLRKEEGVTVSREEFL
QAVRELNPYVNGAARQAIVFEYTDWTEPENPNSNRDALDKMVGDYHFTCNVNEFAQRYAE
EGNNVYMYLYTHRSKGNPWPRWTGVMHGDEINYVFGEPLNSDLGYMEDEKDFSRKIMRYW
SNFAKTGNPNPSPPNSDFPEWPKHTAHGRHYLELGLNTTYVGRGPRLRQCAFWKKYLPQL
VAATSNLQATPAPSEPCGSSATPYRPLLFLIVSLVLVTCFKI
|
|
|
|---|
| BDBM50467883 |
|---|
| n/a |
|---|
| Name | BDBM50467883 |
|---|
| Synonyms: | CHEMBL4287340 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H31N3O3 |
|---|
| Mol. Mass. | 385.4998 |
|---|
| SMILES | CCN1CCN(CC1)C1CCN(CC1)C(=O)COc1ccc2C(=O)CCc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
