| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM50467880 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1797233 (CHEMBL4269350) |
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| IC50 | 16000±n/a nM |
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| Citation |  Knutsson, S; Engdahl, C; Kumari, R; Forsgren, N; Lindgren, C; Kindahl, T; Kitur, S; Wachira, L; Kamau, L; Ekström, F; Linusson, A Noncovalent Inhibitors of Mosquito Acetylcholinesterase 1 with Resistance-Breaking Potency. J Med Chem61:10545-10557 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | Acetylcholinesterase | ace-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78192.84 |
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| Organism: | Aedes aegypti |
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| Description: | ChEMBL_117852 |
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| Residue: | 702 |
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| Sequence: | MEIRGLITRLLGPCHIRHLILCSLGIYSILVQSVHCRHHDIGSSTAHQLGSKYSQSSSLS
SSSQSSSSLVEDPVLNKDSDAFFTPYIGHGDSVRIVDAELGTLEREHVHSTTTRRRGLTR
RESSSDGTDNDPLLITTDKGKVRGLTLEAPSGKKVDAWLGIPYAQPPLGPLRFRHPRPVE
KWTGVLNATTPPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYINVVVPHPRPKNSAVM
LWIFGGGFYSGTATLDVYDHRTLASEENVIVVSLQYRVASLGFLFLGTPEAPGNAGLFDQ
NLALRWVRDNIHKFGGDPSRVTLFGESAGAVSVSLHLLSALSRDLFQRAILQSGSPTAPW
ALVSREEATLRALRLAEAVNCPHDATKLTDTVECLRTKDPNVLVDNEWGTLGICEFPFVP
VVDGAFLDETPQRSLASGRFKKTDILTGSNTEEGYYFIIYYLTELLRKEEGVTVSREEFL
QAVRELNPYVNGAARQAIVFEYTDWTEPENPNSNRDALDKMVGDYHFTCNVNEFAQRYAE
EGNNVYMYLYTHRSKGNPWPRWTGVMHGDEINYVFGEPLNSDLGYMEDEKDFSRKIMRYW
SNFAKTGNPNPSPPNSDFPEWPKHTAHGRHYLELGLNTTYVGRGPRLRQCAFWKKYLPQL
VAATSNLQATPAPSEPCGSSATPYRPLLFLIVSLVLVTCFKI
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| BDBM50467880 |
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| n/a |
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| Name | BDBM50467880 |
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| Synonyms: | CHEMBL4283139 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H31N3O3 |
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| Mol. Mass. | 397.5105 |
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| SMILES | COc1ccc(cc1)-c1ccc(OCC(=O)NCCCN2CCN(C)CC2)cc1 |
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| Structure | 
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