| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Guanine nucleotide-binding protein G(o) subunit alpha |
|---|
| Ligand | BDBM50468898 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1801543 (CHEMBL4273835) |
|---|
| IC50 | >50000±n/a nM |
|---|
| Citation |  Zhang, H; Nielsen, AL; Boesgaard, MW; Harpsøe, K; Daly, NL; Xiong, XF; Underwood, CR; Haugaard-Kedström, LM; Bräuner-Osborne, H; Gloriam, DE; Strømgaard, K Structure-activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359. Eur J Med Chem156:847-860 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Guanine nucleotide-binding protein G(o) subunit alpha |
|---|
| Name: | Guanine nucleotide-binding protein G(o) subunit alpha |
|---|
| Synonyms: | GNAO_RAT | Gna0 | Gnao | Gnao1 | Guanine nucleotide-binding protein G(o) subunit alpha |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 40061.56 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_118030 |
|---|
| Residue: | 354 |
|---|
| Sequence: | MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDG
FSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGVEYGDKERKADSKMVCDVVSRMEDTEPF
SAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRV
KTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDET
TNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYPGSNTYEDA
AAYIQTQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
|
|
|
|---|
| BDBM50468898 |
|---|
| n/a |
|---|
| Name | BDBM50468898 |
|---|
| Synonyms: | CHEMBL4278309 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C50H77N7O15 |
|---|
| Mol. Mass. | 1016.1843 |
|---|
| SMILES | CCCCCC(=O)N[C@@H]([C@H](O)C(C)C)C(=O)O[C@H](C(C)C)[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@@H](C)OC(=O)[C@H]([C@@H](C)OC)N(C)C1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
