Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Monoglyceride lipase |
---|
Ligand | BDBM50414921 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1802954 (CHEMBL4275246) |
---|
IC50 | 140±n/a nM |
---|
Citation | Bononi, G; Granchi, C; Lapillo, M; Giannotti, M; Nieri, D; Fortunato, S; Boustani, ME; Caligiuri, I; Poli, G; Carlson, KE; Kim, SH; Macchia, M; Martinelli, A; Rizzolio, F; Chicca, A; Katzenellenbogen, JA; Minutolo, F; Tuccinardi, T Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors. Eur J Med Chem157:817-836 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Monoglyceride lipase |
---|
Name: | Monoglyceride lipase |
Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
Type: | Hydrolase |
Mol. Mass.: | 33264.56 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
Residue: | 303 |
Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
|
|
|
BDBM50414921 |
---|
n/a |
---|
Name | BDBM50414921 |
Synonyms: | CHEMBL570812 |
Type | Small organic molecule |
Emp. Form. | C18H17N3O5 |
Mol. Mass. | 355.3447 |
SMILES | COc1nn(-c2ccc(NC(=O)OCc3ccccc3)c(C)c2)c(=O)o1 |
Structure |
|