Ki Summary

Reaction Details

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Target

Gonadotropin-releasing hormone receptor

Ligand

BDBM50470102

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_100131 (CHEMBL858015)

1.35±n/a nM

Citation

Haviv, F; Fitzpatrick, TD; Nichols, CJ; Bush, EN; Diaz, G; Bammert, G; Nguyen, AT; Johnson, ES; Knittle, J; Greer, J In vitro and in vivo activities of reduced-size antagonists of luteinizing hormone-releasing hormone. J Med Chem37:701-5 (1994) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gonadotropin-releasing hormone receptor

Name:

Gonadotropin-releasing hormone receptor

Synonyms:

GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr

Type:

PROTEIN

Mol. Mass.:

37767.60

Organism:

Rattus norvegicus

Description:

ChEMBL_1335047

Residue:

327

Sequence:

MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL

BDBM50470102

n/a

Name

BDBM50470102

Synonyms:

CHEMBL405812

Type

Small organic molecule

Emp. Form.

C62H78FN13O10

Mol. Mass.

1184.3622

SMILES

CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCc1cccc(F)c1 |wU:57.63,12.20,wD:45.57,31.44,23.28,5.4,63.67,(27,-7.61,;27.02,-9.14,;25.7,-9.93,;24.36,-9.17,;23.06,-9.93,;24.33,-7.65,;25.54,-6.77,;25.03,-5.33,;23.49,-5.33,;23.07,-6.78,;21.74,-7.52,;21.71,-9.07,;20.39,-6.77,;20.41,-5.22,;21.75,-4.46,;21.77,-2.91,;23.1,-2.16,;23.12,-.62,;24.46,.15,;21.78,.16,;19.07,-7.52,;17.74,-6.75,;17.75,-5.2,;16.39,-7.49,;16.38,-9.04,;17.72,-9.84,;17.68,-11.36,;19.04,-9.06,;15.06,-6.72,;13.72,-7.48,;13.72,-9.01,;12.39,-6.71,;12.42,-5.17,;11.94,-3.71,;10.48,-3.22,;10.48,-1.68,;11.94,-1.2,;12.58,.19,;14.1,.35,;15.01,-.88,;14.38,-2.3,;12.85,-2.46,;11.06,-7.46,;9.72,-6.69,;9.72,-5.14,;8.38,-7.45,;8.36,-8.98,;9.69,-9.77,;9.69,-11.3,;11.03,-12.09,;12.36,-11.33,;13.68,-12.1,;12.38,-9.78,;11.04,-9.01,;7.06,-6.65,;5.72,-7.42,;5.71,-8.98,;4.4,-6.64,;4.4,-5.11,;5.74,-4.35,;3.04,-7.4,;1.72,-6.62,;1.74,-5.1,;.37,-7.39,;.37,-8.93,;1.69,-9.72,;3.11,-9.09,;4.14,-10.23,;3.35,-11.58,;3.82,-13.04,;2.78,-14.17,;1.27,-13.85,;.81,-12.38,;1.85,-11.25,;-.96,-6.62,;-2.29,-7.36,;-2.38,-8.88,;-3.6,-6.55,;-5.1,-7.39,;-6.58,-6.49,;-6.57,-4.78,;-8.03,-3.9,;-9.53,-4.74,;-9.55,-6.46,;-11.12,-7.26,;-8.08,-7.33,)|

Structure