Ki Summary

Reaction Details

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Target

Gonadotropin-releasing hormone receptor

Ligand

BDBM50470116

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_100131 (CHEMBL858015)

0.832±n/a nM

Citation

Haviv, F; Fitzpatrick, TD; Nichols, CJ; Bush, EN; Diaz, G; Bammert, G; Nguyen, AT; Johnson, ES; Knittle, J; Greer, J In vitro and in vivo activities of reduced-size antagonists of luteinizing hormone-releasing hormone. J Med Chem37:701-5 (1994) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gonadotropin-releasing hormone receptor

Name:

Gonadotropin-releasing hormone receptor

Synonyms:

GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr

Type:

PROTEIN

Mol. Mass.:

37767.60

Organism:

Rattus norvegicus

Description:

ChEMBL_1335047

Residue:

327

Sequence:

MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL

BDBM50470116

n/a

Name

BDBM50470116

Synonyms:

CHEMBL262977

Type

Small organic molecule

Emp. Form.

C61H77N13O10

Mol. Mass.

1152.3452

SMILES

CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cc1ccccc1 |wU:57.63,12.20,wD:45.57,31.44,23.28,5.4,63.79,(32.81,-5.09,;32.83,-6.63,;31.49,-7.41,;30.15,-6.64,;28.86,-7.41,;30.12,-5.14,;31.33,-4.24,;30.82,-2.8,;29.31,-2.82,;28.87,-4.26,;27.52,-5.01,;27.52,-6.54,;26.21,-4.24,;26.21,-2.7,;27.56,-1.93,;27.56,-.4,;28.9,.37,;28.92,1.91,;30.25,2.66,;27.59,2.68,;24.86,-5.01,;23.54,-4.23,;23.55,-2.67,;22.2,-4.98,;22.17,-6.53,;23.52,-7.31,;23.49,-8.85,;24.85,-6.54,;20.86,-4.21,;19.52,-4.96,;19.52,-6.5,;18.2,-4.17,;18.2,-2.64,;17.74,-1.19,;16.28,-.7,;16.28,.85,;17.75,1.31,;18.36,2.71,;19.9,2.87,;20.82,1.62,;20.19,.21,;18.65,.05,;16.86,-4.94,;15.53,-4.16,;15.53,-2.63,;14.19,-4.93,;14.19,-6.47,;15.51,-7.25,;15.5,-8.79,;16.83,-9.58,;18.17,-8.82,;19.48,-9.59,;18.17,-7.27,;16.85,-6.48,;12.85,-4.14,;11.53,-4.9,;11.51,-6.45,;10.2,-4.11,;10.2,-2.59,;11.54,-1.84,;8.85,-4.88,;7.51,-4.11,;7.54,-2.57,;6.18,-4.87,;6.16,-6.42,;7.49,-7.19,;8.91,-6.58,;9.94,-7.73,;9.16,-9.04,;9.62,-10.52,;8.58,-11.66,;7.08,-11.34,;6.61,-9.86,;7.65,-8.72,;4.82,-4.05,;3.5,-4.85,;3.56,-6.41,;2.15,-4.11,;.81,-4.93,;.86,-6.48,;-.44,-7.28,;-1.79,-6.58,;-1.85,-5.01,;-.51,-4.21,)|

Structure