Ki Summary

Reaction Details

Report a problem with these data

Target

Gonadotropin-releasing hormone receptor

Ligand

BDBM50470122

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_100131 (CHEMBL858015)

0.039±n/a nM

Citation

Haviv, F; Fitzpatrick, TD; Nichols, CJ; Bush, EN; Diaz, G; Bammert, G; Nguyen, AT; Johnson, ES; Knittle, J; Greer, J In vitro and in vivo activities of reduced-size antagonists of luteinizing hormone-releasing hormone. J Med Chem37:701-5 (1994) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gonadotropin-releasing hormone receptor

Name:

Gonadotropin-releasing hormone receptor

Synonyms:

GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr

Type:

PROTEIN

Mol. Mass.:

37767.60

Organism:

Rattus norvegicus

Description:

ChEMBL_1335047

Residue:

327

Sequence:

MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL

BDBM50470122

n/a

Name

BDBM50470122

Synonyms:

CHEMBL265538

Type

Small organic molecule

Emp. Form.

C63H79F2N13O10

Mol. Mass.

1216.3793

SMILES

CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCc1ccc(F)cc1F |wU:58.64,12.20,wD:31.44,23.28,5.4,64.68,45.48,(29.19,-5.42,;29.2,-6.96,;27.88,-7.74,;26.52,-6.97,;25.23,-7.74,;26.49,-5.48,;27.71,-4.59,;27.2,-3.14,;25.67,-3.16,;25.23,-4.59,;23.91,-5.35,;23.9,-6.87,;22.58,-4.59,;22.59,-3.04,;23.93,-2.27,;23.95,-.74,;25.29,.02,;25.3,1.57,;26.62,2.32,;23.97,2.34,;21.24,-5.33,;19.92,-4.55,;19.92,-3.01,;18.57,-5.32,;18.57,-6.86,;19.89,-7.65,;21.23,-6.87,;19.88,-9.18,;17.24,-4.54,;15.91,-5.29,;15.89,-6.83,;14.59,-4.52,;14.6,-2.97,;14.12,-1.52,;12.67,-1.04,;12.67,.5,;14.14,.99,;14.76,2.37,;16.3,2.53,;17.2,1.29,;16.56,-.13,;15.02,-.27,;13.25,-5.28,;11.92,-4.49,;11.92,-2.96,;10.58,-5.26,;10.57,-6.8,;11.89,-7.58,;13.24,-6.81,;14.57,-7.6,;14.54,-9.15,;15.88,-9.9,;13.22,-9.9,;11.89,-9.13,;9.26,-4.48,;9.26,-2.93,;7.9,-5.23,;7.9,-6.78,;6.58,-4.46,;6.6,-2.93,;7.94,-2.17,;5.25,-5.22,;3.91,-4.45,;3.94,-2.91,;2.58,-5.2,;2.56,-6.74,;3.9,-7.52,;5.32,-6.9,;6.32,-8.05,;5.55,-9.38,;6,-10.86,;4.97,-11.98,;3.48,-11.66,;3.01,-10.19,;4.04,-9.06,;1.26,-4.42,;-.09,-5.16,;-.12,-6.7,;-1.41,-4.39,;-2.89,-5.26,;-4.38,-4.42,;-4.41,-2.72,;-5.92,-1.88,;-7.4,-2.75,;-8.86,-1.85,;-7.37,-4.49,;-5.85,-5.33,;-5.48,-7,)|

Structure