Ki Summary

Reaction Details

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Target

Gonadotropin-releasing hormone receptor

Ligand

BDBM50470128

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_100131 (CHEMBL858015)

0.832±n/a nM

Citation

Haviv, F; Fitzpatrick, TD; Nichols, CJ; Bush, EN; Diaz, G; Bammert, G; Nguyen, AT; Johnson, ES; Knittle, J; Greer, J In vitro and in vivo activities of reduced-size antagonists of luteinizing hormone-releasing hormone. J Med Chem37:701-5 (1994) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gonadotropin-releasing hormone receptor

Name:

Gonadotropin-releasing hormone receptor

Synonyms:

GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr

Type:

PROTEIN

Mol. Mass.:

37767.60

Organism:

Rattus norvegicus

Description:

ChEMBL_1335047

Residue:

327

Sequence:

MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL

BDBM50470128

n/a

Name

BDBM50470128

Synonyms:

CHEMBL439292

Type

Small organic molecule

Emp. Form.

C64H80FN13O9

Mol. Mass.

1194.4001

SMILES

CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCc1ccc(F)cc1 |wU:57.60,12.20,wD:31.44,45.57,23.28,5.4,64.69,(25.56,-6.15,;25.57,-7.67,;24.25,-8.46,;22.9,-7.7,;21.61,-8.46,;22.86,-6.19,;24.09,-5.31,;23.57,-3.87,;22.05,-3.87,;21.61,-5.32,;20.29,-6.06,;20.28,-7.61,;18.96,-5.31,;18.97,-3.77,;20.31,-3,;20.32,-1.46,;21.66,-.71,;21.67,.83,;22.99,1.6,;20.34,1.61,;17.62,-6.06,;16.3,-5.29,;16.3,-3.74,;14.95,-6.03,;14.95,-7.57,;16.26,-8.37,;16.25,-9.89,;17.61,-7.6,;13.63,-5.26,;12.3,-6.02,;12.27,-7.54,;10.98,-5.25,;10.99,-3.71,;10.5,-2.25,;9.06,-1.77,;9.06,-.23,;10.52,.25,;11.15,1.64,;12.68,1.8,;13.58,.57,;12.95,-.85,;11.4,-1.01,;9.63,-6,;8.3,-5.22,;8.3,-3.68,;6.96,-5.99,;6.96,-7.51,;8.28,-8.3,;8.27,-9.85,;9.6,-10.62,;10.94,-9.86,;12.26,-10.63,;10.95,-8.31,;9.62,-7.54,;5.64,-5.19,;4.31,-5.95,;4.29,-7.51,;2.97,-5.16,;3.48,-3.84,;2.26,-3.2,;1.3,-4.16,;1.64,-5.93,;.3,-5.16,;.33,-3.64,;-1.03,-5.92,;-1.05,-7.47,;.29,-8.25,;1.71,-7.63,;2.71,-8.77,;1.94,-10.11,;2.39,-11.57,;1.36,-12.69,;-.13,-12.37,;-.6,-10.91,;.43,-9.78,;-2.35,-5.16,;-3.69,-5.9,;-3.63,-7.41,;-5.07,-5.22,;-6.49,-6.22,;-8.04,-5.51,;-8.21,-3.81,;-9.77,-3.09,;-11.19,-4.09,;-12.7,-3.29,;-11,-5.8,;-9.43,-6.51,)|

Structure