| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase catalytic subunit |
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| Ligand | BDBM50027539 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_50629 |
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| IC50 | 87000±n/a nM |
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| Citation |  Norén, JO; Helgstrand, E; Johansson, NG; Misiorny, A; Stening, G Synthesis of esters of phosphonoformic acid and their antiherpes activity. J Med Chem26:264-70 (1983) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase catalytic subunit |
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| Name: | DNA polymerase catalytic subunit |
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| Synonyms: | DPOL_HHV11 | Human herpesvirus 1 DNA polymerase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 136432.57 |
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| Organism: | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1) |
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| Description: | ChEMBL_321605 |
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| Residue: | 1235 |
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| Sequence: | MFSGGGGPLSPGGKSAARAASGFFAPAGPRGASRGPPPCLRQNFYNPYLAPVGTQQKPTG
PTQRHTYYSECDEFRFIAPRVLDEDAPPEKRAGVHDGHLKRAPKVYCGGDERDVLRVGSG
GFWPRRSRLWGGVDHAPAGFNPTVTVFHVYDILENVEHAYGMRAAQFHARFMDAITPTGT
VITLLGLTPEGHRVAVHVYGTRQYFYMNKEEVDRHLQCRAPRDLCERMAAALRESPGASF
RGISADHFEAEVVERTDVYYYETRPALFYRVYVRSGRVLSYLCDNFCPAIKKYEGGVDAT
TRFILDNPGFVTFGWYRLKPGRNNTLAQPAAPMAFGTSSDVEFNCTADNLAIEGGMSDLP
AYKLMCFDIECKAGGEDELAFPVAGHPEDLVIQISCLLYDLSTTALEHVLLFSLGSCDLP
ESHLNELAARGLPTPVVLEFDSEFEMLLAFMTLVKQYGPEFVTGYNIINFDWPFLLAKLT
DIYKVPLDGYGRMNGRGVFRVWDIGQSHFQKRSKIKVNGMVNIDMYGIITDKIKLSSYKL
NAVAEAVLKDKKKDLSYRDIPAYYAAGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELSA
VARLAGINITRTIYDGQQIRVFTCLLRLADQKGFILPDTQGRFRGAGGEAPKRPAAARED
EERPEEEGEDEDEREEGGGEREPEGARETAGRHVGYQGARVLDPTSGFHVNPVVVFDFAS
LYPSIIQAHNLCFSTLSLRADAVAHLEAGKDYLEIEVGGRRLFFVKAHVRESLLSILLRD
WLAMRKQIRSRIPQSSPEEAVLLDKQQAAIKVVCNSVYGFTGVQHGLLPCLHVAATVTTI
GREMLLATREYVHARWAAFEQLLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAA
GLTAVGDKMASHISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKMLIKGVDLVRK
NNCAFINRTSRALVDLLFYDDTVSGAAAALAERPAEEWLARPLPEGLQAFGAVLVDAHRR
ITDPERDIQDFVLTAELSRHPRAYTNKRLAHLTVYYKLMARRAQVPSIKDRIPYVIVAQT
REVEETVARLAALRELDAAAPGDEPAPPAALPSPAKRPRETPSPADPPGGASKPRKLLVS
ELAEDPAYAIAHGVALNTDYYFSHLLGAACVTFKALFGNNAKITESLLKRFIPEVWHPPD
DVAARLRTAGFGAVGAGATAEETRRMLHRAFDTLA
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| BDBM50027539 |
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| n/a |
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| Name | BDBM50027539 |
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| Synonyms: | CHEMBL90955 | disodium (4-methylphenoxy)(oxido)phosphinecarboxylate oxide |
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| Type | Small organic molecule |
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| Emp. Form. | C8H7O5P |
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| Mol. Mass. | 214.113 |
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| SMILES | Cc1ccc(OP([O-])(=O)C([O-])=O)cc1 |
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| Structure | 
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