| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 |
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| Ligand | BDBM50475953 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_410133 (CHEMBL908895) |
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| EC50 | 3.89±n/a nM |
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| Citation |  Altenbach, RJ; Brune, ME; Buckner, SA; Coghlan, MJ; Daza, AV; Fabiyi, A; Gopalakrishnan, M; Henry, RF; Khilevich, A; Kort, ME; Milicic, I; Scott, VE; Smith, JC; Whiteaker, KL; Carroll, WA Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener. J Med Chem49:6869-87 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 |
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| Name: | ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11 |
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| Synonyms: | Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 | Sulfonylurea receptor 2, Kir6.2 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 46128 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | ATP-binding cassette sub-family C member 9 |
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| Synonyms: | ABCC9 | ABCC9_HUMAN | ATP-binding cassette transporter sub-family C member 9 | SUR2 | Sulfonylurea receptor 2 | Sulfonylurea receptor 2, Kir6.2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 174236.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_495672 |
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| Residue: | 1549 |
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| Sequence: | MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHH
NTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIV
YYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLL
MAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHK
KPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLS
STFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFL
ALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIE
TNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEA
QKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSI
FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAII
SVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTR
RLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILG
EMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQR
YKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFS
ALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQ
TKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE
EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTS
EYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGP
IRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALL
PLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLE
LTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITN
YLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVR
YENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKL
PLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDA
VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTV
VTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK
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| Component 2 |
| Name: | ATP-sensitive inward rectifier potassium channel 11 |
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| Synonyms: | ATP-sensitive inward rectifier potassium channel 11 | IKATP | Inward rectifier K(+) channel Kir6.2 | KCJ11_HUMAN | KCNJ11 | Potassium channel, inwardly rectifying subfamily J member 11 | Potassium channel, inwardly rectifying, subfamily J, member 11 | Sulfonylurea receptor 1, Kir6.2 | Sulfonylurea receptor 2, Kir6.2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43549.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Potassium channel (ATP modulatory) 0 0::Q14654 |
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| Residue: | 390 |
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| Sequence: | MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVF
TTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSA
FLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAET
LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPM
ENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQA
RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALT
LASARGPLRKRSVPMAKAKPKFSISPDSLS
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| BDBM50475953 |
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| n/a |
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| Name | BDBM50475953 |
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| Synonyms: | CHEMBL384564 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15BrFNO4 |
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| Mol. Mass. | 408.218 |
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| SMILES | CC[C@@H]1OC(O)=C2[C@@H](C3=C(COCC3=O)N=C12)c1ccc(F)c(Br)c1 |t:5,8,16| |
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| Structure | 
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