Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M1

Ligand

BDBM50092975

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_442218 (CHEMBL892377)

96±n/a nM

Citation

Niu, YY; Yang, LM; Deng, KM; Yao, JH; Zhu, L; Chen, CY; Zhang, M; Zhou, JE; Shen, TX; Chen, HZ; Lu, Y Quantitative structure-selectivity relationship for M2 selectivity between M1 and M2 of piperidinyl piperidine derivatives as muscarinic antagonists. Bioorg Med Chem Lett17:2260-6 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M1

Name:

Muscarinic acetylcholine receptor M1

Synonyms:

ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1

Type:

Protein

Mol. Mass.:

51442.54

Organism:

Homo sapiens (Human)

Description:

P11229

Residue:

460

Sequence:

MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

BDBM50092975

n/a

Name

BDBM50092975

Synonyms:

1-(4-(4-(1-(4-(4-methoxyphenylsulfonyl)phenyl)vinyl)piperidin-1-yl)piperidin-1-yl)-2-phenylethanone | 1-(4-{1-[4-(4-Methoxy-benzenesulfonyl)-phenyl]-vinyl}-[1,4']bipiperidinyl-1'-yl)-2-phenyl-ethanone | CHEMBL72787

Type

Small organic molecule

Emp. Form.

C33H38N2O4S

Mol. Mass.

558.731

SMILES

COc1ccc(cc1)S(=O)(=O)c1ccc(cc1)C(=C)C1CCN(CC1)C1CCN(CC1)C(=O)Cc1ccccc1

Structure