| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM50476747 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_446257 (CHEMBL895361) |
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| Ki | 0.758578±n/a nM |
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| Citation |  Fedi, V; Altamura, M; Catalioto, RM; Giannotti, D; Giolitti, A; Giuliani, S; Guidi, A; Harmat, NJ; Lecci, A; Meini, S; Nannicini, R; Pasqui, F; Tramontana, M; Triolo, A; Maggi, CA Discovery of a new series of potent and selective linear tachykinin NK2 receptor antagonists. J Med Chem50:4793-807 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3 |
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| Type: | Protein |
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| Mol. Mass.: | 44455.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21452 |
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| Residue: | 398 |
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| Sequence: | MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
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| BDBM50476747 |
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| n/a |
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| Name | BDBM50476747 |
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| Synonyms: | CHEMBL394350 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H45N5O5S |
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| Mol. Mass. | 659.838 |
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| SMILES | O=C(CCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(CCCC1)NC(=O)c1cc2ccccc2s1)N1CCC(CC1)N1CCOCC1 |
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| Structure | 
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