Reaction Details |
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Target | Presenilin-1 |
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Ligand | BDBM50477917 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_461557 (CHEMBL928698) |
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IC50 | 1.1±n/a nM |
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Citation | Bergstrom, CP; Sloan, CP; Wang, HH; Parker, MF; Smith, DW; Zheng, M; Hansel, SB; Polson, CT; Barber, LE; Bursuker, I; Guss, VL; Corsa, JA; Barten, DM; Felsenstein, KM; Roberts, SB Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase. Bioorg Med Chem Lett18:175-8 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Presenilin-1 |
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Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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BDBM50477917 |
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n/a |
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Name | BDBM50477917 |
Synonyms: | CHEMBL253295 |
Type | Small organic molecule |
Emp. Form. | C21H26Cl2N2O5S2 |
Mol. Mass. | 521.478 |
SMILES | C[C@H](CCCN1CCCS1(=O)=O)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 |
Structure |
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