| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50477996 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_463503 (CHEMBL932798) |
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| IC50 | 61±n/a nM |
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| Citation |  Dayam, R; Al-Mawsawi, LQ; Zawahir, Z; Witvrouw, M; Debyser, Z; Neamati, N Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors. J Med Chem51:1136-44 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50477996 |
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| n/a |
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| Name | BDBM50477996 |
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| Synonyms: | CHEMBL272193 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23N7O2 |
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| Mol. Mass. | 369.4209 |
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| SMILES | CCOc1cc(ccc1\C=C1\C(C)=NN(C1=O)c1nnn[nH]1)N(CC)CC |c:13| |
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| Structure | 
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