| Reaction Details |
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 | Report a problem with these data |
| Target | 1,3-beta-glucan synthase |
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| Ligand | BDBM50417554 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_472363 (CHEMBL952166) |
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| IC50 | 16.3±n/a nM |
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| Citation |  Paderu, P; Garcia-Effron, G; Balashov, S; Delmas, G; Park, S; Perlin, DS Serum differentially alters the antifungal properties of echinocandin drugs. Antimicrob Agents Chemother51:2253-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1,3-beta-glucan synthase |
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| Name: | 1,3-beta-glucan synthase |
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| Synonyms: | GSL2 | Glucan synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 189382.66 |
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| Organism: | Candida albicans |
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| Description: | ChEMBL_19912 |
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| Residue: | 1640 |
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| Sequence: | MFDYLMRLLDSRTSRLGPTHALRSIHADYIGGMNSNFRKWYFAAQLDIDDFVGFDNLAKN
GKIKGSNDPVATLEQAESQWSTNMLALSPTDSVIQLAIYLLIWGEANNIRFMPECICFIF
KCCNDFYFSIDPDTPVTTVTPSFLDHIITPLYNFYRDQSYILVDGKYRRRDKDHESVIGY
DDMNQLFWYSKGLERLVLADKKSRLMSLPPGERYEELNQVLWNRVFYKTFKENRGWSHVL
VNFHRVWIIHSAVFWYYTAFNSPTLYTKNYQPALDNQPTTQARLSVLAFGGVVAIVIDII
SLLFELRFIPRKWTGAQPVSKRLALLILALILNVGPSVYLFMFIPLNVQNTVGLVISAFQ
FSFSVIMVLYLSTVPLGRLFSKKPKANDRRFLPQRSFVTNFYSLAEGDRVASYGLWFAIF
VSKFIESYFFLTLSLRDPVRELSIMKMSRCAGEVWLGNWFCTRQPTIVLGLIYLTDLVLF
ILDTYLWYIVWNTVFSVCRSFYIGVSIWTPWRNIFSRLPKRIFSKIISVSGDKNIKSKLL
VSQVWNSIIISMYREHLISLEHVQKLIYKQIDNPGVEGDSVLKEPIFFVSQEDQTIKSSL
FQDQAEAQRRITFFAQSLSTPMPEVGPVHLMPSFTVLIPHYSEKITLSLREIIREEEQYS
HVTMLEYLKSLHPLEWSCFVKDTKLLAEEFETDSSSAEIKREKLDDLPYYSVGFKVATPE
YILRTRIWASLRSQTLYRTISGFMNYSRAIKLLFDVENPDSTKFGTENDKLEQAAIMAHR
KFRIITSMQRLKYFTPEEKENTEFLLRAYPELQICYLDEEVDEASGEIVYYSALVDGSCA
IMENGEREPKYRIRLSGNPILGDGKSDNQNHSLIFCRGEYIQLVDANQDNYLEECLKIRS
ILAEFEEATFPLDPYSTDLEGTESVYPVAIIGTREYIFSENIGILGDVAAGKEQTFGTLF
ARTLAHIGGKLHYGHPDFLNGIFMTTRGGVSKAQKGLHLNEDIYAGMNVVLRGGRIKHCE
YMQCGKGRDLGFGSILNFTTKIGAGMGEQMLSREYFYMGTQLPLDRFLSFYYAHSGFHLN
NLFIMLSIHLFLLVGANLAALTSESTICEYDRFRPITDPKRPHGCYNLIPVVHWLQRCIF
SIFIVFVISFVPLAVQELTERGFYKAITRLGKQFASFSPLFEVFVCKIYAHSLSSDISIG
GARYLATGRGFATIRVPFATLYSRFAVESLYYGSICGLLIFYCSLSMWKLQLLYFWITIL
GLLICPFLYNPNQFSWNDFFLDYKECIQWFYRGNSKPRLSSWINFTRLKRSRIVGVKSKR
YSINEEIKVVSEVKPSRFKLIISESFLQLCVITLVGLAYLFTNSQNGSRGTYPVNSILRI
LIISFVPIGVNLVILIACFVVSISIGPIFTLFCKKFPSFVAAIAHLLAVANHVFFFELLW
LFQNWNFSVTVLGFALSALIQCWFLQMMTILLVSREFRHDRSNRSWWSGKWATAGLGWYI
ITQPMREAVCKLSEMSYFAGDLVATHIILFAQIPILLIPYADKWHTLMLFWLKPGNQIRP
RILSKRQKRRRRFQANLYLLIFLLGLILFSSIFVLPLIATKYFDIEFSEYIPEFFHPLFQ
PYDAPTNSKGLKKKLEIKHY
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| BDBM50417554 |
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| n/a |
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| Name | BDBM50417554 |
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| Synonyms: | ANIDULAFUNGIN |
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| Type | Small organic molecule |
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| Emp. Form. | C58H73N7O17 |
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| Mol. Mass. | 1140.2369 |
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| SMILES | CCCCCOc1ccc(cc1)-c1ccc(cc1)-c1ccc(cc1)C(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@@H](C)CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)c1ccc(O)cc1)[C@@H](C)O |r| |
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| Structure | 
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