Reaction Details |
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Target | Presenilin-1 |
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Ligand | BDBM50477339 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_477733 (CHEMBL926067) |
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IC50 | 12±n/a nM |
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Citation | Iben, LG; Olson, RE; Balanda, LA; Jayachandra, S; Robertson, BJ; Hay, V; Corradi, J; Prasad, CV; Zaczek, R; Albright, CF; Toyn, JH Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology. J Biol Chem282:36829-36 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Presenilin-1 |
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Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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BDBM50477339 |
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n/a |
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Name | BDBM50477339 |
Synonyms: | BMS-299897 | CHEMBL247471 |
Type | Small organic molecule |
Emp. Form. | C24H21ClF3NO4S |
Mol. Mass. | 511.941 |
SMILES | C[C@@H](N(c1cc(F)ccc1F)S(=O)(=O)c1ccc(Cl)cc1)c1ccc(F)cc1CCCC(O)=O |r| |
Structure |
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