| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Presenilin-1 |
|---|
| Ligand | BDBM50478375 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_477733 (CHEMBL926067) |
|---|
| IC50 | 6.3±n/a nM |
|---|
| Citation |  Iben, LG; Olson, RE; Balanda, LA; Jayachandra, S; Robertson, BJ; Hay, V; Corradi, J; Prasad, CV; Zaczek, R; Albright, CF; Toyn, JH Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology. J Biol Chem282:36829-36 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Presenilin-1 |
|---|
| Name: | Presenilin-1 |
|---|
| Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 52657.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49768 |
|---|
| Residue: | 467 |
|---|
| Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
|
|
|
|---|
| BDBM50478375 |
|---|
| n/a |
|---|
| Name | BDBM50478375 |
|---|
| Synonyms: | CHEBI:86193 | CHEMBL255682 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H26F2N2O4 |
|---|
| Mol. Mass. | 432.4603 |
|---|
| SMILES | C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@H](C(=O)OC(C)(C)C)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
