| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Putative penicillin-binding protein 2B |
|---|
| Ligand | BDBM50378857 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_553824 (CHEMBL966187) |
|---|
| IC50 | 187±n/a nM |
|---|
| Citation |  Davies, TA; Page, MG; Shang, W; Andrew, T; Kania, M; Bush, K Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrob Agents Chemother51:2621-4 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Putative penicillin-binding protein 2B |
|---|
| Name: | Putative penicillin-binding protein 2B |
|---|
| Synonyms: | B9Z04_05970 | B9Z08_04335 | Cell division protein FtsI (Peptidoglycan synthetase) | EP54_05770 | EQ90_05620 | ERS072738_01739 | HMPREF3211_00860 | Penicillin-binding protein | Penicillin-binding protein 1 | Putative penicillin-binding protein 2B | Synonyms=ftsI_2 | pbp1 | pbpA |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 82733.22 |
|---|
| Organism: | Staphylococcus aureus |
|---|
| Description: | ChEMBL_105733 |
|---|
| Residue: | 744 |
|---|
| Sequence: | MAKQKIKIKKNKIGAVLLVGLFGLLFFILVLRISYIMITGHSNGQDLVMKANEKYLVKNA
QQPERGKIYDRNGKVLAEDVERYKLVAVIDKKASANSKKPRHVVDKKETAKKLSTVINMK
PEEIEKRLSQKKAFQIEFGRKGTNLTYQDKLKIEKMNLPGISLLPETERFYPNGNFASHL
IGRAQKNPDTGELKGALGVEKIFDSYLSGSKGSLRYIHDIWGYIAPNTKKEKQPKRGDDV
HLTIDSNIQVFVEEALDGMVERYQPKDLFAVVMDAKTGEILAYSQRPTFNPETGKDFGKK
WANDLYQNTYEPGSTFKSYGLAAAIQEGAFDPDKKYKSGHRDIMGSRISDWNRVGWGEIP
MSLGFTYSSNTLMMHLQDLVGADKMKSWYERFGFGKSTKGMFDGEAPGQIGWSNELQQKT
SSFGQSTTVTPVQMLQAQSAFFNDGNMLKPWFVNSVENPVSKRQFYKGQKQIAGKPITKD
TAEKVEKQLDLVVNSKKSHAANYRIDGYEVEGKTGTAQVAAPNGGGYVKGPNPYFVSFMG
DAPKKNPKVIVYAGMSLAQKNDQEAYELGVSKAFKPIMENTLKYLNVGKSKDDTSNAEYS
KVPDVEGQDKQKAIDNVSAKSLEPVTIGSGTQIKAQSIKAGNKVLPHSKVLLLTDGDLTM
PDMSGWTKEDVIAFENLTNIKVNLKGSGFVSHQSISKGQKLTEKDKIDVEFSSENVDSNS
TNNSDSNSDDKKKSDSKTDKDKSD
|
|
|
|---|
| BDBM50378857 |
|---|
| n/a |
|---|
| Name | BDBM50378857 |
|---|
| Synonyms: | CEFTOBIPROLE | Zeftera | Zevtera |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22N8O6S2 |
|---|
| Mol. Mass. | 534.569 |
|---|
| SMILES | Nc1nc(ns1)C(N=O)C(=O)N[C@H]1[C@H]2SCC(C=C3CCN([C@@H]4CCNC4)C3=O)=C(N2C1=O)C(O)=O |r,w:17.17,c:31| |
|---|
| Structure | 
|
|---|
Search and Browse
