| Reaction Details |
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 | Report a problem with these data |
| Target | Peptidoglycan D,D-transpeptidase MrdA |
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| Ligand | BDBM50213266 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_553672 (CHEMBL960465) |
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| IC50 | 334±n/a nM |
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| Citation |  Davies, TA; Page, MG; Shang, W; Andrew, T; Kania, M; Bush, K Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrob Agents Chemother51:2621-4 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptidoglycan D,D-transpeptidase MrdA |
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| Name: | Peptidoglycan D,D-transpeptidase MrdA |
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| Synonyms: | 3.4.16.4 | AO964_03845 | AOY09_05445 | C0046_27725 | C8257_05325 | CAZ03_33860 | CAZ10_26315 | CGU42_07245 | CRX60_00455 | DC19_04850 | DI492_29940 | DN070_10950 | DZ934_12725 | DZ940_19030 | DZ962_23955 | E4V10_04960 | EQH76_28325 | IPC3_29275 | IPC669_09400 | NCTC13719_00971 | PAERUG_E15_London_28_01_14_04647 | PBP-2 | Penicillin-binding protein 2 | Peptidoglycan D,D-transpeptidase MrdA | RW109_RW109_01676 | pbpA | spoVD |
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| Type: | PROTEIN |
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| Mol. Mass.: | 72223.59 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | ChEMBL_105732 |
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| Residue: | 646 |
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| Sequence: | MPQPIHLKDHEKDARLVRRRVIVGAVAVVLLTLVLVARMYHLQVTQYEYHSTLSENNRVH
VQPIPPTRGIIFDRNGVIIADNRPSFSLTITRERTEDLQKTLDTLVEILGLTEDDRAIFE
KRMKQGRRPFEPVPIMFELNEEQIARIAVNQFRLPGVDVATQFVRHYPLKEHFAHSVGYV
GRINEQELKNLDPINYSGTHHIGKTGIERFYESELHGTVGYEEVETNARGRVLRVLKRTD
PIPGKDIVLSIDSRLQEAAENALAGRRGAIVAIQPSTGDVLAMVSQPSYDPNLFVTGISF
KAYAELRDSIDRPLYNRVLRGLYPPGSTVKPAVALAGLDAGVVTPTSRVFDPGYYQLPNY
DHKYRNWNRYGDGWVSLESAIYRSNDTYFYDLAHKLGIDRLHAFMSRFGFGQKVALDMFG
EADGLMPSREWKRKTRRQVWYPGETLILGIGQGYMQATPIQLAQMTALLANKGHWIRPHL
AKTIDGQPPVDPDPMPDIVLRDPANWDRVDYGMQQVVHGARGTARKVGATSAYLIAGKSG
TAQVVAIKQNERYDRSKLLERHRDHALFVGFAPANNPQIAVAVMVENGESGSGVAAPVVK
QVMDAWLLDEHGKLKAEYAEPVAPLAAAVAKPEPTAAEPEAPALEQ
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| BDBM50213266 |
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| n/a |
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| Name | BDBM50213266 |
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| Synonyms: | CHEBI:471744 | Imipenem | MK-0787 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H17N3O4S |
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| Mol. Mass. | 299.346 |
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| SMILES | [H][C@]12CC(SCCNC=N)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=O |r,c:9| |
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| Structure | 
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