Reaction Details |
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Target | Integrase |
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Ligand | BDBM28236 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_535569 (CHEMBL987043) |
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IC50 | 33±n/a nM |
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Citation | Melamed, JY; Egbertson, MS; Varga, S; Vacca, JP; Moyer, G; Gabryelski, L; Felock, PJ; Stillmock, KA; Witmer, MV; Schleif, W; Hazuda, DJ; Leonard, Y; Jin, L; Ellis, JD; Young, SD Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase. Bioorg Med Chem Lett18:5307-10 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Integrase |
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Name: | Integrase |
Synonyms: | pol |
Type: | PROTEIN |
Mol. Mass.: | 32203.43 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_106649 |
Residue: | 288 |
Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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BDBM28236 |
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n/a |
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Name | BDBM28236 |
Synonyms: | CHEMBL199145 | N-[(4-fluorophenyl)methyl]-8-hydroxy-1,6-naphthyridine-7-carboxamide | naphthyridine carboxamide, 21 |
Type | Small organic molecule |
Emp. Form. | C16H12FN3O2 |
Mol. Mass. | 297.2838 |
SMILES | Oc1c(ncc2cccnc12)C(=O)NCc1ccc(F)cc1 |
Structure |
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