| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50479410 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_559817 (CHEMBL1020688) |
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| IC50 | 170±n/a nM |
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| Citation |  Ferro, S; De Luca, L; Barreca, ML; Iraci, N; De Grazia, S; Christ, F; Witvrouw, M; Debyser, Z; Chimirri, A Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions. J Med Chem52:569-73 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50479410 |
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| n/a |
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| Name | BDBM50479410 |
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| Synonyms: | CHEMBL498204 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18F3NO5 |
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| Mol. Mass. | 433.3772 |
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| SMILES | CCOC(=O)C(\O)=C\C(=O)c1cn(Cc2c(F)ccc(F)c2F)c2cccc(OC)c12 |
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| Structure | 
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