Reaction Details |
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Target | Integrase |
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Ligand | BDBM50479828 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_542592 (CHEMBL1014188) |
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IC50 | 900±n/a nM |
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Citation | Sechi, M; Rizzi, G; Bacchi, A; Carcelli, M; Rogolino, D; Pala, N; Sanchez, TW; Taheri, L; Dayam, R; Neamati, N Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors. Bioorg Med Chem17:2925-35 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Integrase |
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Name: | Integrase |
Synonyms: | pol |
Type: | PROTEIN |
Mol. Mass.: | 32203.43 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_106649 |
Residue: | 288 |
Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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BDBM50479828 |
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n/a |
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Name | BDBM50479828 |
Synonyms: | CHEMBL464215 |
Type | Small organic molecule |
Emp. Form. | C18H14FNO4 |
Mol. Mass. | 327.3065 |
SMILES | Cn1c2ccc(Cc3ccc(F)cc3)cc2c(O)c(C(O)=O)c1=O |
Structure |
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