| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
|---|
| Ligand | BDBM50482065 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_627582 (CHEMBL1113588) |
|---|
| IC50 | 4720±n/a nM |
|---|
| Citation |  Cheng, K; Zheng, QZ; Hou, J; Zhou, Y; Liu, CH; Zhao, J; Zhu, HL Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics. Bioorg Med Chem18:2447-55 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
|---|
| Name: | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
|---|
| Synonyms: | 3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 33506.68 |
|---|
| Organism: | Escherichia coli |
|---|
| Description: | C3TDZ2 |
|---|
| Residue: | 317 |
|---|
| Sequence: | MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAAT
RAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALS
VADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLH
ADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDW
LVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVL
LEAFGGGFTWGSALVRF
|
|
|
|---|
| BDBM50482065 |
|---|
| n/a |
|---|
| Name | BDBM50482065 |
|---|
| Synonyms: | CHEMBL1091660 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H18Cl2N2O3 |
|---|
| Mol. Mass. | 381.253 |
|---|
| SMILES | CC(CNC(=O)c1ccc(C)cc1O)\N=C\c1cc(Cl)cc(Cl)c1O |
|---|
| Structure | 
|
|---|
Search and Browse
