| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50482537 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_647171 (CHEMBL1217312) |
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| IC50 | 130±n/a nM |
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| Citation |  Ferro, S; De Luca, L; Barreca, ML; De Grazia, S; Christ, F; Debyser, Z; Chimirri, A New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action. Bioorg Med Chem18:5510-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50482537 |
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| n/a |
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| Name | BDBM50482537 |
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| Synonyms: | CHEMBL1213723 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16ClNO5 |
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| Mol. Mass. | 385.798 |
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| SMILES | COc1cccc2n(Cc3cccc(Cl)c3)cc(C(=O)\C=C(/O)C(O)=O)c12 |
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| Structure | 
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