| Reaction Details |
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 | Report a problem with these data |
| Target | Penicillin-binding protein 2x |
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| Ligand | BDBM50482776 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_672077 (CHEMBL1267458) |
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| IC50 | 365±n/a nM |
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| Citation |  Kosowska-Shick, K; McGhee, PL; Appelbaum, PC Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. Antimicrob Agents Chemother54:1670-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Penicillin-binding protein 2x |
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| Name: | Penicillin-binding protein 2x |
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| Synonyms: | PBPX_STRPN | pbpX |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82307.00 |
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| Organism: | Streptococcus pneumoniae |
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| Description: | ChEMBL_653273 |
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| Residue: | 750 |
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| Sequence: | MKWTKRVIRYATKNRKSPAENRRRVGKSLSLLSVFVFAIFLVNFAVIIGTGTRFGTDLAK
EAKKVHQTTRTVPAKRGTIYDRNGVPIAEDATSYNVYAVIDENYKSATGKILYVEKTQFN
KVAEVFHKYLDMEESYVREQLSQPNLKQVSFGAKGNGITYANMMSIKKELEAAEVKGIDF
TTSPNRSYPNGQFASSFIGLAQLHENEDGSKSLLGTSGMESSLNSILAGTDGIITYEKDR
LGNIVPGTEQVSQRTMDGKDVYTTISSPLQSFMETQMDAFQEKVKGKYMTATLVSAKTGE
ILATTQRPTFDADTKEGITEDFVWRDILYQSNYEPGSTMKVMMLAAAIDNNTFPGGEVFN
SSELKIADATIRDWDVNEGLTGGRTMTFSQGFAHSSNVGMTLLEQKMGDATWLDYLNRFK
FGVPTRFGLTDEYAGQLPADNIVNIAQSSFGQGISVTQTQMIRAFTAIANDGVMLEPKFI
SAIYDPNDQTARKSQKEIVGNPVSKDAASLTRTNMVLVGTDPVYGTMYNHSTGKPTVTVP
GQNVALKSGTAQIADEKNGGYLVGLTDYIFSAVSMSPAENPDFILYVTVQQPEHYSGIQL
GEFANPILERASAMKDSLNLQTTAKALEQVSQQSPYPMPSVKDISPGDLAEELRRNLVQP
IVVGTGTKIKNSSAEEGKNLAPNQQVLILSDKAEEVPDMYGWTKETAETLAKWLNIELEF
QGSGSTVQKQDVRANTAIKDIKKITLTLGD
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| BDBM50482776 |
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| n/a |
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| Name | BDBM50482776 |
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| Synonyms: | CHEBI:70718 | Ceftaroline Fosamil | PPI-0903 | TAK-599 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21N8O8PS4 |
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| Mol. Mass. | 684.685 |
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| SMILES | [H][C@]12SCC(Sc3nc(cs3)-c3cc[n+](C)cc3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OCC)\c1nsc(NP(O)(O)=O)n1)C([O-])=O |r,c:19| |
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| Structure | 
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