| Reaction Details |
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 | Report a problem with these data |
| Target | Penicillin-binding protein 2B |
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| Ligand | BDBM50482777 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_672085 (CHEMBL1267466) |
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| IC50 | 35100±n/a nM |
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| Citation |  Kosowska-Shick, K; McGhee, PL; Appelbaum, PC Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. Antimicrob Agents Chemother54:1670-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Penicillin-binding protein 2B |
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| Name: | Penicillin-binding protein 2B |
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| Synonyms: | PBP2_STRPN | Penicillin-binding protein 2B | pbp2b | pbp2b | penA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73859.38 |
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| Organism: | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
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| Description: | ChEMBL_103544 |
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| Residue: | 680 |
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| Sequence: | MRKFNSHSIPIRLNLLFSIVILLFMTIIGRLLYMQVLNKDFYEKKLASASQTKITSSSAR
GEIYDASGKPLVENTLKQVVSFTRSNKMTATDLKETAKKLLTYVSISSPNLTERQLADYY
LADPEIYKKIVEALPSEKRLDSDGNRLSESELYNNAVDSVQTSQLNYTEDEKKEIYLFSQ
LNAVGNFATGTIATDPLNDSQVAVIASISKEMPGISISTSWDRKVLETSLSSIVGSVSSE
KAGLPAEEAEAYLKKGYSLNDRVGTSYLEKQYEETLQGKRSVKEIHLDKYGNMESVDTIE
EGSKGNNIKLTIDLAFQDSVDALLKSYFNSELENGGAKYSEGVYAVALNPKTGAVLSMSG
IKHDLKTGELTPDSLGTVTNVFVPGSVVKAATISSGWENGVLSGNQTLTDQSIVFQGSAP
INSWYTQAYGSFPITAVQALEYSSNTYMVQTALGLMGQTYQPNMFVGTSNLESAMEKLRS
TFGEYGLGTATGIDLPDESTGFVPKEYSFANYITNAFGQFDNYTPMQLAQYVATIANNGV
RVAPRIVEGIYGNNDKGGLGDLIQQLQPTEMNKVNISDSDMSILHQGFYQVAHGTSGLTT
GRAFSNGALVSISGKTGTAESYVADGQQATNTNAVAYAPSDNPQIAVAVVFPHNTNLTNG
VGPSIARDIINLYQKYHPMN
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| BDBM50482777 |
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| n/a |
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| Name | BDBM50482777 |
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| Synonyms: | CHEBI:204928 | Cefotaxime |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17N5O7S2 |
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| Mol. Mass. | 455.465 |
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| SMILES | [H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c1csc(N)n1)C(O)=O |c:9| |
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| Structure | 
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