| Reaction Details |
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 | Report a problem with these data |
| Target | 1,3-beta-D-glucan synthase catalytic subunit |
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| Ligand | BDBM50483463 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_727762 (CHEMBL1686121) |
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| IC50 | 501±n/a nM |
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| Citation |  Ting, PC; Kuang, R; Wu, H; Aslanian, RG; Cao, J; Kim, DW; Lee, JF; Schwerdt, J; Zhou, G; Wainhaus, S; Black, TA; Cacciapuoti, A; McNicholas, PM; Xu, Y; Walker, SS The synthesis and structure-activity relationship of pyridazinones as glucan synthase inhibitors. Bioorg Med Chem Lett21:1819-22 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1,3-beta-D-glucan synthase catalytic subunit |
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| Name: | 1,3-beta-D-glucan synthase catalytic subunit |
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| Synonyms: | 1,3-beta-D-glucan synthase catalytic subunit | Beta-1,3-glucan synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 80469.77 |
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| Organism: | Candida albicans |
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| Description: | ChEMBL_663643 |
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| Residue: | 690 |
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| Sequence: | GTIYWMYTAYNSPTLYTKHYVQTINQQPLASSRWAACAIGGVLASFIQILATLFEWIFVP
REWAGAQHLSRRMLFLVLIFLLNLVPPVYTFQITKLVIYSKSAYAVSIVGFFIAVATLVF
FAVMPLGGLFTSYMNKRSRRYIASQTFTANYIKLKGLDMWMSYLLWFLVFLAKLVESYFF
LTLSLRDPIRNLSTMTMRCVGEVWYKDIVCRNQAKIVLGLMYLVDLLLFFLDTYMWYIIC
NCIFSIGRSFYLGISILTPWRNIFTRLPKRIYSKILATTEMEIKYKPKVLISQIWNAIVI
SMYREHLLAIDHVQKLLYHQVPSEIEGKRTLRAPTFFVSQDDNNFETEFFPRNSEAERRI
SFFAQSLATPMPEPLPVDNMPTFTVFTPHYSEKILLSLREIIREDDQFSRVTLLEYLKQL
HPVEWDCFVKDTKILAEETAAYENGDDSEKLSEDGLKSKIDDLPFYCIGFKSAAPEYTLR
TRIWASLRSQTLYRTVSGFMNYARAIKLLYRVENPELVQYFGGDPEGLELALERMARRKF
RFLVSMQRLSKFKDDEMENAEFLLRAYPDLQIAYLDEEPALNEDEEPRVYSALIDGHCEM
LENGRRRPKFRVQLSGNPILGDGKSDNQNHAVIFHRGEYIQLIDANQDNYLEECLKIRSV
LAEFEEMNVEHVNPYAPNLKSEDNNTKKDP
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| BDBM50483463 |
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| n/a |
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| Name | BDBM50483463 |
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| Synonyms: | CHEMBL1684891 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H28ClFN4O4S |
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| Mol. Mass. | 498.999 |
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| SMILES | CC(C)S(=O)(=O)N1CCN(CC1)c1cnn(-c2cc(F)cc(Cl)c2)c(=O)c1OC1CCCC1 |
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| Structure | 
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