| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50476348 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_727385 (CHEMBL1685113) |
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| IC50 | 600±n/a nM |
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| Citation |  Sharma, H; Patil, S; Sanchez, TW; Neamati, N; Schinazi, RF; Buolamwini, JK Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors. Bioorg Med Chem19:2030-45 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | pol |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32203.43 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_106649 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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| BDBM50476348 |
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| n/a |
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| Name | BDBM50476348 |
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| Synonyms: | GSK-S-1360 | GW-810781 | Gw810781 | S 1360 | S-1360 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12FN3O3 |
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| Mol. Mass. | 313.2832 |
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| SMILES | O\C(=C/C(=O)c1ccc(Cc2ccc(F)cc2)o1)c1nc[nH]n1 |
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| Structure | 
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