Reaction Details |
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Target | Presenilin-1 |
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Ligand | BDBM50483739 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_745100 (CHEMBL1772226) |
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IC50 | >10000±n/a nM |
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Citation | Brodney, MA; Auperin, DD; Becker, SL; Bronk, BS; Brown, TM; Coffman, KJ; Finley, JE; Hicks, CD; Karmilowicz, MJ; Lanz, TA; Liston, D; Liu, X; Martin, BA; Nelson, RB; Nolan, CE; Oborski, CE; Parker, CP; Richter, KE; Pozdnyakov, N; Sahagan, BG; Schachter, JB; Sokolowski, SA; Tate, B; Van Deusen, JW; Wood, DE; Wood, KM Diamide amino-imidazoles: a novel series of ?-secretase inhibitors for the treatment of Alzheimer's disease. Bioorg Med Chem Lett21:2631-6 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Presenilin-1 |
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Name: | Presenilin-1 |
Synonyms: | 3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182 |
Type: | n/a |
Mol. Mass.: | 52657.13 |
Organism: | Homo sapiens (Human) |
Description: | P49768 |
Residue: | 467 |
Sequence: | MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSR
QVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTE
DTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFI
YLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKY
LPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAE
GDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAA
VQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCL
TLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
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BDBM50483739 |
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n/a |
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Name | BDBM50483739 |
Synonyms: | CHEMBL1770892 |
Type | Small organic molecule |
Emp. Form. | C25H34F2N6O3 |
Mol. Mass. | 504.5727 |
SMILES | CN(C)C(=O)C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(cn1)C(C)(C)CN1CCCC1 |r| |
Structure |
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