| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Integrase |
|---|
| Ligand | BDBM50065786 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_749291 (CHEMBL1785226) |
|---|
| IC50 | 3020±n/a nM |
|---|
| Citation |  Leonard, JT; Roy, K Exploring molecular shape analysis of styrylquinoline derivatives as HIV-1 integrase inhibitors. Eur J Med Chem43:81-92 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Integrase |
|---|
| Name: | Integrase |
|---|
| Synonyms: | pol |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 32203.43 |
|---|
| Organism: | Human immunodeficiency virus 1 |
|---|
| Description: | ChEMBL_106649 |
|---|
| Residue: | 288 |
|---|
| Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
|
|
|
|---|
| BDBM50065786 |
|---|
| n/a |
|---|
| Name | BDBM50065786 |
|---|
| Synonyms: | 2-[(E)-2-(3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carbonitrile | 2-[2-(3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carbonitrile | CHEMBL59446 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H12N2O3 |
|---|
| Mol. Mass. | 304.2995 |
|---|
| SMILES | Oc1ccc(\C=C\c2ccc3ccc(C#N)c(O)c3n2)cc1O |
|---|
| Structure | 
|
|---|
Search and Browse
