| Reaction Details |
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 | Report a problem with these data |
| Target | AP2-associated protein kinase 1 |
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| Ligand | BDBM279457 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1806412 (CHEMBL4305771) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Verdonck, S; Pu, SY; Sorrell, FJ; Elkins, JM; Froeyen, M; Gao, LJ; Prugar, LI; Dorosky, DE; Brannan, JM; Barouch-Bentov, R; Knapp, S; Dye, JM; Herdewijn, P; Einav, S; De Jonghe, S Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity. J Med Chem62:5810-5831 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| AP2-associated protein kinase 1 |
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| Name: | AP2-associated protein kinase 1 |
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| Synonyms: | AAK1 | AAK1_HUMAN | Adaptor-associated kinase 1 | KIAA1048 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103884.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774569 |
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| Residue: | 961 |
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| Sequence: | MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV
FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW
EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE
NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT
TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK
RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT
ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP
AQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ
QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ
PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA
AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG
EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI
PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL
ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID
L
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| BDBM279457 |
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| n/a |
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| Name | BDBM279457 |
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| Synonyms: | (R)-1-(5-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)-1H-benzo[d]imidazol-2-yl)-3-methylbutan-1-amine | US10035777, Example 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20N6 |
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| Mol. Mass. | 320.3916 |
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| SMILES | CC(C)C[C@@H](N)c1nc2cc(ccc2[nH]1)-c1ncnc2[nH]ccc12 |r| |
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| Structure | 
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