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Target1,3-beta-D-glucan synthase catalytic subunit
LigandBDBM50485331
Substrate/Competitorn/a
Meas. Tech.ChEMBL_827592 (CHEMBL2049671)
IC50 87.9±n/a nM
Citation Zych, AJLam, SQJenkins, DMHerr, RJTing, PCLee, JFKuang, RWu, HKim, DWAslanian, RGWainhaus, SBlack, TACacciapuoti, AMcNicholas, PMXu, YWalker, SS Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors. Bioorg Med Chem Lett22:4896-9 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
1,3-beta-D-glucan synthase catalytic subunit
Name:1,3-beta-D-glucan synthase catalytic subunit
Synonyms:1,3-beta-D-glucan synthase catalytic subunit | Beta-1,3-glucan synthase
Type:PROTEIN
Mol. Mass.:80469.77
Organism:Candida albicans
Description:ChEMBL_663643
Residue:690
Sequence:
GTIYWMYTAYNSPTLYTKHYVQTINQQPLASSRWAACAIGGVLASFIQILATLFEWIFVP
REWAGAQHLSRRMLFLVLIFLLNLVPPVYTFQITKLVIYSKSAYAVSIVGFFIAVATLVF
FAVMPLGGLFTSYMNKRSRRYIASQTFTANYIKLKGLDMWMSYLLWFLVFLAKLVESYFF
LTLSLRDPIRNLSTMTMRCVGEVWYKDIVCRNQAKIVLGLMYLVDLLLFFLDTYMWYIIC
NCIFSIGRSFYLGISILTPWRNIFTRLPKRIYSKILATTEMEIKYKPKVLISQIWNAIVI
SMYREHLLAIDHVQKLLYHQVPSEIEGKRTLRAPTFFVSQDDNNFETEFFPRNSEAERRI
SFFAQSLATPMPEPLPVDNMPTFTVFTPHYSEKILLSLREIIREDDQFSRVTLLEYLKQL
HPVEWDCFVKDTKILAEETAAYENGDDSEKLSEDGLKSKIDDLPFYCIGFKSAAPEYTLR
TRIWASLRSQTLYRTVSGFMNYARAIKLLYRVENPELVQYFGGDPEGLELALERMARRKF
RFLVSMQRLSKFKDDEMENAEFLLRAYPDLQIAYLDEEPALNEDEEPRVYSALIDGHCEM
LENGRRRPKFRVQLSGNPILGDGKSDNQNHAVIFHRGEYIQLIDANQDNYLEECLKIRSV
LAEFEEMNVEHVNPYAPNLKSEDNNTKKDP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50485331
n/a
NameBDBM50485331
Synonyms:CHEMBL2046603
TypeSmall organic molecule
Emp. Form.C26H32ClN5O4S
Mol. Mass.546.081
SMILESClc1cccc(NC(=O)C(\OC2CCCC2)=C(/C=N)N2CCN(CC2)S(=O)(=O)NCc2ccccc2)c1
Structure
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