| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 1,3-beta-D-glucan synthase catalytic subunit |
|---|
| Ligand | BDBM50485334 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_827592 (CHEMBL2049671) |
|---|
| IC50 | 521±n/a nM |
|---|
| Citation |  Zych, AJ; Lam, SQ; Jenkins, DM; Herr, RJ; Ting, PC; Lee, JF; Kuang, R; Wu, H; Kim, DW; Aslanian, RG; Wainhaus, S; Black, TA; Cacciapuoti, A; McNicholas, PM; Xu, Y; Walker, SS Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors. Bioorg Med Chem Lett22:4896-9 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 1,3-beta-D-glucan synthase catalytic subunit |
|---|
| Name: | 1,3-beta-D-glucan synthase catalytic subunit |
|---|
| Synonyms: | 1,3-beta-D-glucan synthase catalytic subunit | Beta-1,3-glucan synthase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 80469.77 |
|---|
| Organism: | Candida albicans |
|---|
| Description: | ChEMBL_663643 |
|---|
| Residue: | 690 |
|---|
| Sequence: | GTIYWMYTAYNSPTLYTKHYVQTINQQPLASSRWAACAIGGVLASFIQILATLFEWIFVP
REWAGAQHLSRRMLFLVLIFLLNLVPPVYTFQITKLVIYSKSAYAVSIVGFFIAVATLVF
FAVMPLGGLFTSYMNKRSRRYIASQTFTANYIKLKGLDMWMSYLLWFLVFLAKLVESYFF
LTLSLRDPIRNLSTMTMRCVGEVWYKDIVCRNQAKIVLGLMYLVDLLLFFLDTYMWYIIC
NCIFSIGRSFYLGISILTPWRNIFTRLPKRIYSKILATTEMEIKYKPKVLISQIWNAIVI
SMYREHLLAIDHVQKLLYHQVPSEIEGKRTLRAPTFFVSQDDNNFETEFFPRNSEAERRI
SFFAQSLATPMPEPLPVDNMPTFTVFTPHYSEKILLSLREIIREDDQFSRVTLLEYLKQL
HPVEWDCFVKDTKILAEETAAYENGDDSEKLSEDGLKSKIDDLPFYCIGFKSAAPEYTLR
TRIWASLRSQTLYRTVSGFMNYARAIKLLYRVENPELVQYFGGDPEGLELALERMARRKF
RFLVSMQRLSKFKDDEMENAEFLLRAYPDLQIAYLDEEPALNEDEEPRVYSALIDGHCEM
LENGRRRPKFRVQLSGNPILGDGKSDNQNHAVIFHRGEYIQLIDANQDNYLEECLKIRSV
LAEFEEMNVEHVNPYAPNLKSEDNNTKKDP
|
|
|
|---|
| BDBM50485334 |
|---|
| n/a |
|---|
| Name | BDBM50485334 |
|---|
| Synonyms: | CHEMBL2046745 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H35ClN6O4S |
|---|
| Mol. Mass. | 575.123 |
|---|
| SMILES | CC(NS(=O)(=O)N1CCN(CC1)C(\C=N)=C(/OCC1(C)CC1)C(=O)Nc1cccc(Cl)c1)c1cccc(N)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
