| Reaction Details |
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 | Report a problem with these data |
| Target | 1,3-beta-D-glucan synthase catalytic subunit |
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| Ligand | BDBM50485335 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_827592 (CHEMBL2049671) |
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| IC50 | 157±n/a nM |
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| Citation |  Zych, AJ; Lam, SQ; Jenkins, DM; Herr, RJ; Ting, PC; Lee, JF; Kuang, R; Wu, H; Kim, DW; Aslanian, RG; Wainhaus, S; Black, TA; Cacciapuoti, A; McNicholas, PM; Xu, Y; Walker, SS Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors. Bioorg Med Chem Lett22:4896-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1,3-beta-D-glucan synthase catalytic subunit |
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| Name: | 1,3-beta-D-glucan synthase catalytic subunit |
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| Synonyms: | 1,3-beta-D-glucan synthase catalytic subunit | Beta-1,3-glucan synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 80469.77 |
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| Organism: | Candida albicans |
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| Description: | ChEMBL_663643 |
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| Residue: | 690 |
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| Sequence: | GTIYWMYTAYNSPTLYTKHYVQTINQQPLASSRWAACAIGGVLASFIQILATLFEWIFVP
REWAGAQHLSRRMLFLVLIFLLNLVPPVYTFQITKLVIYSKSAYAVSIVGFFIAVATLVF
FAVMPLGGLFTSYMNKRSRRYIASQTFTANYIKLKGLDMWMSYLLWFLVFLAKLVESYFF
LTLSLRDPIRNLSTMTMRCVGEVWYKDIVCRNQAKIVLGLMYLVDLLLFFLDTYMWYIIC
NCIFSIGRSFYLGISILTPWRNIFTRLPKRIYSKILATTEMEIKYKPKVLISQIWNAIVI
SMYREHLLAIDHVQKLLYHQVPSEIEGKRTLRAPTFFVSQDDNNFETEFFPRNSEAERRI
SFFAQSLATPMPEPLPVDNMPTFTVFTPHYSEKILLSLREIIREDDQFSRVTLLEYLKQL
HPVEWDCFVKDTKILAEETAAYENGDDSEKLSEDGLKSKIDDLPFYCIGFKSAAPEYTLR
TRIWASLRSQTLYRTVSGFMNYARAIKLLYRVENPELVQYFGGDPEGLELALERMARRKF
RFLVSMQRLSKFKDDEMENAEFLLRAYPDLQIAYLDEEPALNEDEEPRVYSALIDGHCEM
LENGRRRPKFRVQLSGNPILGDGKSDNQNHAVIFHRGEYIQLIDANQDNYLEECLKIRSV
LAEFEEMNVEHVNPYAPNLKSEDNNTKKDP
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| BDBM50485335 |
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| n/a |
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| Name | BDBM50485335 |
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| Synonyms: | CHEMBL2046748 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H35ClN6O5S |
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| Mol. Mass. | 591.122 |
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| SMILES | COc1cc(CNS(=O)(=O)N2CCN(CC2)C(\C=N)=C(/OCC2(C)CC2)C(=O)Nc2cccc(Cl)c2)ccc1N |
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| Structure | 
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