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TargetGamma-aminobutyric acid type B receptor subunit 1
LigandBDBM50032995
Substrate/Competitorn/a
Meas. Tech.ChEMBL_68561 (CHEMBL679648)
IC50 14000±n/a nM
Citation Froestl, WMickel, SJvon Sprecher, GDiel, PJHall, RGMaier, LStrub, DMelillo, VBaumann, PABernasconi, R Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists. J Med Chem38:3313-31 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Gamma-aminobutyric acid type B receptor subunit 1
Name:Gamma-aminobutyric acid type B receptor subunit 1
Synonyms:GABA B | GABA B receptor | GABA uptake | GABA-B receptor 1 | GABA-B-R1 | GABA-BR1 | GABABR1 | GABR1_RAT | Gabbr1 | Gb1
Type:Enzyme Catalytic Domain
Mol. Mass.:111548.69
Organism:Rattus norvegicus (Rat)
Description:Q9Z0U4
Residue:991
Sequence:
MLLLLLVPLFLRPLGAGGAQTPNATSEGCQIIHPPWEGGIRYRGLTRDQVKAINFLPVDY
EIEYVCRGEREVVGPKVRKCLANGSWTDMDTPSRCVRICSKSYLTLENGKVFLTGGDLPA
LDGARVEFRCDPDFHLVGSSRSVCSQGQWSTPKPHCQVNRTPHSERRAVYIGALFPMSGG
WPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKII
LMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLF
EKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARI
IVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKTYDPSINCTVEEMTEAVEG
HITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALAL
NKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQ
LQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSL
GIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRSQFPF
VCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMD
VLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSKKMNTWLGELWSFAVSSD
VQRRATVGGDSPICVWPAPESIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIY
NVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSET
QDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPT
PPDPSGGLPRGPSEPPDRLSCDGSRVHLLYK
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  Blast E-value cutoff:
BDBM50032995
n/a
NameBDBM50032995
Synonyms:(3-Amino-2-oxo-propyl)-cyclopropylmethyl-phosphinic acid | CHEMBL325932
TypeSmall organic molecule
Emp. Form.C7H14NO3P
Mol. Mass.191.1647
SMILES[#7]-[#6]-[#6](=O)-[#6]P([#8])([#8])\[#6]=[#6]-1\[#6]-[#6]-1
Structure
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