Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50033554 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_52992 (CHEMBL665261) |
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IC50 | 410±n/a nM |
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Citation | Gangjee, A; Zaveri, N; Kothare, M; Queener, SF Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities. J Med Chem38:3660-8 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 23891.29 |
Organism: | Pneumocystis carinii |
Description: | n/a |
Residue: | 206 |
Sequence: | MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
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BDBM50033554 |
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n/a |
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Name | BDBM50033554 |
Synonyms: | 6-[(2,5-Dichloro-phenylamino)-methyl]-5,6,7,8-tetrahydro-quinazoline-2,4-diamine | CHEMBL121319 |
Type | Small organic molecule |
Emp. Form. | C15H17Cl2N5 |
Mol. Mass. | 338.235 |
SMILES | Nc1nc(N)c2CC(CNc3cc(Cl)ccc3Cl)CCc2n1 |
Structure |
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