| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50033555 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_55140 (CHEMBL668783) |
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| IC50 | 74±n/a nM |
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| Citation |  Gangjee, A; Zaveri, N; Kothare, M; Queener, SF Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities. J Med Chem38:3660-8 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21638.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
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|
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| BDBM50033555 |
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| n/a |
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| Name | BDBM50033555 |
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| Synonyms: | 6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-5,6,7,8-tetrahydro-quinazoline-2,4-diamine | CHEMBL120821 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27N5O3 |
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| Mol. Mass. | 397.4708 |
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| SMILES | COc1cc(cc(OC)c1OC)N(CC#C)CC1CCc2nc(N)nc(N)c2C1 |
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| Structure | 
|
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