| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50033557 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_52993 (CHEMBL664424) |
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| IC50 | 300±n/a nM |
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| Citation |  Gangjee, A; Zaveri, N; Kothare, M; Queener, SF Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities. J Med Chem38:3660-8 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 23891.29 |
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| Organism: | Pneumocystis carinii |
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| Description: | n/a |
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| Residue: | 206 |
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| Sequence: | MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
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| BDBM50033557 |
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| n/a |
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| Name | BDBM50033557 |
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| Synonyms: | 6-{[(2,5-Dimethoxy-phenyl)-methyl-amino]-methyl}-5,6,7,8-tetrahydro-quinazoline-2,4-diamine | CHEMBL121868 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H25N5O2 |
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| Mol. Mass. | 343.4234 |
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| SMILES | COc1ccc(OC)c(c1)N(C)CC1CCc2nc(N)nc(N)c2C1 |
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| Structure | 
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