| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50034255 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63197 (CHEMBL873588) |
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| IC50 | 1300±n/a nM |
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| Citation |  Doherty, AM; Patt, WC; Edmunds, JJ; Berryman, KA; Reisdorph, BR; Plummer, MS; Shahripour, A; Lee, C; Cheng, XM; Walker, DM Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists. J Med Chem38:1259-63 (1995) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50034255 |
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| n/a |
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| Name | BDBM50034255 |
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| Synonyms: | 3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-phenyl-5H-furan-2-one | CHEMBL11131 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18O5 |
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| Mol. Mass. | 386.3967 |
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| SMILES | OC1(OC(=O)C(=C1Cc1ccccc1)c1ccc2OCOc2c1)c1ccccc1 |c:5| |
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| Structure | 
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