Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50029772 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54750 (CHEMBL667808) |
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IC50 | 22±n/a nM |
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Citation | Gangjee, A; Vasudevan, A; Queener, SF; Kisliuk, RL 6-substituted 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents. J Med Chem38:1778-85 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_LACCA | dhfR | folA |
Type: | PROTEIN |
Mol. Mass.: | 18437.08 |
Organism: | Lactobacillus casei |
Description: | ChEMBL_1357878 |
Residue: | 163 |
Sequence: | MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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BDBM50029772 |
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n/a |
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Name | BDBM50029772 |
Synonyms: | 5-Methyl-6-[(3,4,5-trimethoxy-phenylamino)-methyl]-pyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL23532 |
Type | Small organic molecule |
Emp. Form. | C18H22N6O3 |
Mol. Mass. | 370.4057 |
SMILES | COc1cc(NCc2cnc3nc(N)nc(N)c3c2C)cc(OC)c1OC |
Structure |
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