Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50034938 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54750 (CHEMBL667808) |
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IC50 | 39±n/a nM |
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Citation | Gangjee, A; Vasudevan, A; Queener, SF; Kisliuk, RL 6-substituted 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents. J Med Chem38:1778-85 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_LACCA | dhfR | folA |
Type: | PROTEIN |
Mol. Mass.: | 18437.08 |
Organism: | Lactobacillus casei |
Description: | ChEMBL_1357878 |
Residue: | 163 |
Sequence: | MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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BDBM50034938 |
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n/a |
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Name | BDBM50034938 |
Synonyms: | 6-[(2,5-Dimethoxy-phenylamino)-methyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL23021 |
Type | Small organic molecule |
Emp. Form. | C17H20N6O2 |
Mol. Mass. | 340.3797 |
SMILES | COc1ccc(OC)c(NCc2cnc3nc(N)nc(N)c3c2C)c1 |
Structure |
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