Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50034937 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54967 (CHEMBL875140) |
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IC50 | 17.5±n/a nM |
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Citation | Gangjee, A; Vasudevan, A; Queener, SF; Kisliuk, RL 6-substituted 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents. J Med Chem38:1778-85 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21638.84 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
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BDBM50034937 |
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n/a |
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Name | BDBM50034937 |
Synonyms: | 6-{[Isopropyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL53693 |
Type | Small organic molecule |
Emp. Form. | C21H28N6O3 |
Mol. Mass. | 412.4854 |
SMILES | COc1cc(cc(OC)c1OC)N(Cc1cnc2nc(N)nc(N)c2c1C)C(C)C |
Structure |
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