| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA gyrase subunit B |
|---|
| Ligand | BDBM50490570 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_945576 (CHEMBL2344503) |
|---|
| IC50 | 200000±n/a nM |
|---|
| Citation |  Gomez, C; Ponien, P; Serradji, N; Lamouri, A; Pantel, A; Capton, E; Jarlier, V; Anquetin, G; Aubry, A Synthesis of gatifloxacin derivatives and their biological activities against Mycobacterium leprae and Mycobacterium tuberculosis. Bioorg Med Chem21:948-56 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA gyrase subunit B |
|---|
| Name: | DNA gyrase subunit B |
|---|
| Synonyms: | 5.6.2.2 | DNA gyrase subunit B | GYRB_MYCTU | gyrB |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 74087.83 |
|---|
| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
|---|
| Description: | ChEMBL_109655 |
|---|
| Residue: | 675 |
|---|
| Sequence: | MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
YATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGL
HGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVF
ETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAES
TAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISV
KVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKK
INKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARR
SFITRNAKDVRFLDV
|
|
|
|---|
| BDBM50490570 |
|---|
| n/a |
|---|
| Name | BDBM50490570 |
|---|
| Synonyms: | CHEMBL2338469 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H24FN3O6 |
|---|
| Mol. Mass. | 433.4302 |
|---|
| SMILES | CCN1CCN(CC1C(O)=O)c1c(F)cc2c(c1OC)n(cc(C(O)=O)c2=O)C1CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
