| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit B |
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| Ligand | BDBM50490574 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_945576 (CHEMBL2344503) |
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| IC50 | 65100±n/a nM |
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| Citation |  Gomez, C; Ponien, P; Serradji, N; Lamouri, A; Pantel, A; Capton, E; Jarlier, V; Anquetin, G; Aubry, A Synthesis of gatifloxacin derivatives and their biological activities against Mycobacterium leprae and Mycobacterium tuberculosis. Bioorg Med Chem21:948-56 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit B |
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| Name: | DNA gyrase subunit B |
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| Synonyms: | 5.6.2.2 | DNA gyrase subunit B | GYRB_MYCTU | gyrB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74087.83 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | ChEMBL_109655 |
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| Residue: | 675 |
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| Sequence: | MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
YATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGL
HGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVF
ETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAES
TAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISV
KVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKK
INKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARR
SFITRNAKDVRFLDV
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| BDBM50490574 |
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| n/a |
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| Name | BDBM50490574 |
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| Synonyms: | CHEMBL2338462 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29FN4O5 |
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| Mol. Mass. | 460.4986 |
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| SMILES | CCCCNC(=O)OCC1CN(CCN1)c1cc2n(cc(C(O)=O)c(=O)c2cc1F)C1CC1 |
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| Structure | 
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