Reaction Details |
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Target | Type-1 angiotensin II receptor |
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Ligand | BDBM50490704 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_948640 (CHEMBL2345156) |
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IC50 | 331±n/a nM |
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Citation | Agelis, G; Resvani, A; Koukoulitsa, C; T?mová, T; Slaninová, J; Kalavrizioti, D; Spyridaki, K; Afantitis, A; Melagraki, G; Siafaka, A; Gkini, E; Megariotis, G; Grdadolnik, SG; Papadopoulos, MG; Vlahakos, D; Maragoudakis, M; Liapakis, G; Mavromoustakos, T; Matsoukas, J Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers. Eur J Med Chem62:352-70 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Type-1 angiotensin II receptor |
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Name: | Type-1 angiotensin II receptor |
Synonyms: | AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1) |
Type: | Protein |
Mol. Mass.: | 41080.75 |
Organism: | Homo sapiens (Human) |
Description: | P30556 |
Residue: | 359 |
Sequence: | MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
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BDBM50490704 |
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n/a |
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Name | BDBM50490704 |
Synonyms: | CHEMBL2337684 |
Type | Small organic molecule |
Emp. Form. | C35H33BrN2O4 |
Mol. Mass. | 625.552 |
SMILES | [Br-].CCCCc1c[n+](Cc2ccc(cc2)-c2ccccc2C(O)=O)cn1Cc1ccc(cc1)-c1ccccc1C(O)=O |
Structure |
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