Reaction Details |
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Target | Sodium- and chloride-dependent GABA transporter 2 |
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Ligand | BDBM50491708 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_962082 (CHEMBL2388199) |
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IC50 | 66069±n/a nM |
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Citation | Quandt, G; Höfner, G; Wanner, KT Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors. Bioorg Med Chem21:3363-78 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent GABA transporter 2 |
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Name: | Sodium- and chloride-dependent GABA transporter 2 |
Synonyms: | GABA transporter | GABA transporter 3 | Gabt2 | Gabt3 | Gat-3 | Gat2 | Gat3 | S6A13_MOUSE | Slc6a13 |
Type: | PROTEIN |
Mol. Mass.: | 68283.40 |
Organism: | Mus musculus |
Description: | ChEMBL_1460089 |
Residue: | 602 |
Sequence: | MENRASGTTSNGETKPVCPAMEKVEEDGTLEREHWNNKMEFVLSVAGEIIGLGNVWRFPY
LCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQM
IVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKANDSMNVTSENAT
SPVIEFWERRVLKLSDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATF
PYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTAL
GSYNKYHNNCYRDCIALCILNSSTSFMAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI
AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREVLI
LIVSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAGRFYDNI
EDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS
SMICIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKNQPEPTAPATPMTSLLRLTELES
NC
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BDBM50491708 |
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n/a |
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Name | BDBM50491708 |
Synonyms: | CHEMBL2387659 |
Type | Small organic molecule |
Emp. Form. | C23H23F2NO4 |
Mol. Mass. | 415.4298 |
SMILES | OC(=O)C1CCCN(CCO\C=C/c2ccc(F)cc2C(=O)c2ccccc2F)C1 |
Structure |
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