| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 1 |
|---|
| Ligand | BDBM50491711 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_962083 (CHEMBL2388200) |
|---|
| IC50 | 10715±n/a nM |
|---|
| Citation |  Quandt, G; Höfner, G; Wanner, KT Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors. Bioorg Med Chem21:3363-78 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium- and chloride-dependent GABA transporter 1 |
|---|
| Name: | Sodium- and chloride-dependent GABA transporter 1 |
|---|
| Synonyms: | GABA transporter | Gabt1 | Gat-1 | Gat1 | SC6A1_RAT | Slc6a1 | Solute carrier family 6 member 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 67006.26 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1472611 |
|---|
| Residue: | 599 |
|---|
| Sequence: | MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
|
|
|
|---|
| BDBM50491711 |
|---|
| n/a |
|---|
| Name | BDBM50491711 |
|---|
| Synonyms: | CHEMBL2387658 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H23F2NO4 |
|---|
| Mol. Mass. | 415.4298 |
|---|
| SMILES | OC(=O)C1CCCN(CCO\C=C\c2ccc(F)cc2C(=O)c2ccccc2F)C1 |
|---|
| Structure | 
|
|---|
Search and Browse
