Reaction Details |
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Target | Sodium- and chloride-dependent GABA transporter 1 |
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Ligand | BDBM50080337 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_962083 (CHEMBL2388200) |
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IC50 | 14±n/a nM |
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Citation | Quandt, G; Höfner, G; Wanner, KT Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors. Bioorg Med Chem21:3363-78 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent GABA transporter 1 |
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Name: | Sodium- and chloride-dependent GABA transporter 1 |
Synonyms: | GABA transporter | Gabt1 | Gat-1 | Gat1 | SC6A1_RAT | Slc6a1 | Solute carrier family 6 member 1 |
Type: | PROTEIN |
Mol. Mass.: | 67006.26 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1472611 |
Residue: | 599 |
Sequence: | MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
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BDBM50080337 |
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n/a |
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Name | BDBM50080337 |
Synonyms: | (R)-1-{2-[2,2-Bis-(3-methyl-thiophen-2-yl)-vinyloxy]-ethyl}-piperidine-3-carboxylic acid; hydrochloride | CHEMBL554210 |
Type | Small organic molecule |
Emp. Form. | C20H25NO3S2 |
Mol. Mass. | 391.547 |
SMILES | [#6]-c1ccsc1\[#6](=[#6]/[#8]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6@H](-[#6]-1)-[#6](-[#8])=O)-c1sccc1-[#6] |
Structure |
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