| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA:cholesterol acyltransferase |
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| Ligand | BDBM50040829 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_28192 (CHEMBL637685) |
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| IC50 | 110±n/a nM |
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| Citation |  Kumazawa, T; Yanase, M; Harakawa, H; Obase, H; Shirakura, S; Ohishi, E; Oda, S; Kubo, K; Yamada, K Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Synthesis and hypocholesterolemic activity of dibenz[b,e]oxepin-11-carboxanilides. J Med Chem37:804-10 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Acyl-CoA:cholesterol acyltransferase |
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| Name: | Acyl-CoA:cholesterol acyltransferase |
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| Synonyms: | ACAT |
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| Type: | n/a |
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| Mol. Mass.: | 35405.31 |
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| Organism: | Oryctolagus cuniculus |
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| Description: | n/a |
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| Residue: | 305 |
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| Sequence: | PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
|
|
|
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| BDBM50040829 |
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| n/a |
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| Name | BDBM50040829 |
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| Synonyms: | 2-Methyl-6,11-dihydro-dibenzo[b,e]oxepine-11-carboxylic acid (2,4,6-trimethyl-phenyl)-amide | CHEMBL353082 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25NO2 |
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| Mol. Mass. | 371.4715 |
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| SMILES | Cc1ccc2OCc3ccccc3C(C(=O)Nc3c(C)cc(C)cc3C)c2c1 |
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| Structure | 
|
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