| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50041095 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_162032 (CHEMBL770312) |
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| IC50 | 180±n/a nM |
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| Citation |  Guida, WC; Elliott, RD; Thomas, HJ; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Ealick, SE; Montgomery, JA Structure-based design of inhibitors of purine nucleoside phosphorylase. 4. A study of phosphate mimics. J Med Chem37:1109-14 (1994) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Inosine phosphorylase | Np | PNPH_RAT | Pnp | Purine nucleoside phosphorylase | Purine-nucleoside phosphorylase | nucleoside phosphorylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32303.61 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_162034 |
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| Residue: | 289 |
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| Sequence: | MENEFTYEDYQRTAEWLRSHTKHRPQVAVICGSGLGGLTAKLTQPQAFDYNEIPNFPQST
VQGHAGRLVFGFLNGRSCVMMQGRFHMYEGYSLSKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFCGQNPLRGPNDERFGVRFPAMSDAYDRDMRQKAFNAWKQ
MGEQRELQEGTYIMSAGPTFETVAESCLLRMLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVVMDYNNLEKASHQEVLEAGKAAAQKLEQFVSILMESIPPRERAN
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| BDBM50041095 |
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| n/a |
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| Name | BDBM50041095 |
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| Synonyms: | 5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-3,3-dimethyl-pentane-1-sulfonic acid | CHEMBL13415 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H19N5O4S |
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| Mol. Mass. | 329.375 |
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| SMILES | CC(C)(CCn1cnc2c1nc(N)[nH]c2=O)CCS(O)(=O)=O |
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| Structure | 
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